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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

Fig. 7

Dex-induced OHT leads to axonal transport deficits in mice. C57BL/6 J mice treated with Veh and Dex for 10 weeks and injected intravitreally with red fluorescently tagged CTB dye (Alexa fluor 555). The proximal (close to ONH) and distal (close to optic chiasm) regions of optic nerve are marked in DIC image of optic nerve on the upper panel. Veh-injected mice showed an uninterrupted axoplasmic anterograde transportation of CTB along the entire length of optic nerve including both proximal and distal regions. However, CTB transport was blocked completely at ONH and no CTB was detected in distal region of optic nerve (n = 4)

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Molecular Neurodegeneration

ISSN: 1750-1326