Fig. 2
From: Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration
sTREM2 attenuates ApoE4 effects on cognitive decline and neurodegeneration. Panels a-c illustrate the interaction effect of sTREM2 on longitudinal ApoE4-related changes in global cognition (a), memory (b) and hippocampal volume changes (c) in the pooled Aβ+/Aβ- sample. For illustrational purposes, the sTREM2 levels are split at the median for ApoE4 negative and ApoE4 positive subjects. Statistics were, however, computed using continuous sTREM2 measures. In order to illustrate the sTREM2 effects on cognition and hippocampal volume changes independent of primary AD pathology y-axis are residualized for CSF Aβ1–42 and p-tau181. Panels d-f illustrate the same interaction effects of sTREM2 on longitudinal ApoE4-related changes restricted to Aβ + subjects