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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model

Fig. 1

Expression of Dendra2 and TauT4 from a single-copy transgene in C. elegans touch neurons. DIC (a, e) and confocal fluorescent images (b, c, d, f, g, and h) are shown of L4 larval worms expressing single-copy transgenes coding for Dendra2 (b, c, d) or a Dendra2::TauT4 translational fusion (f, g, h). The transgenes are driven by the mec-7 promoter in ALM(L/R) and PLM(L/R) neuron pairs, and also in AVM and PVM neurons, which are not considered further here. Panels c, g and d, h are magnifications of ALM and PLM respectively in the areas encompassed by the white boxes in panels (b and f). Scale bars: 25 μm. ALM is Anterior Lateral Microtubule and PLM is Posterior Lateral Microtubule cells, mechanosensory neurons that mediate behavioral responses to light touch to the body wall within the receptive fields defined by their projections

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Molecular Neurodegeneration

ISSN: 1750-1326