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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease

Fig. 5

Time-dependent TAU hyperphosphorylation. a Representative confocal images of marker expression in the indicated hiBFCNs at 52 dpi. Cell soma and nucleus are outlined, respectively. Scale bar, 10 μm. b Quantification of soma AT8 expression in the indicated hiBFCNs at 52 dpi. The dots indicate single cells (mean ± SEM; n = 40 for NL1; n = 41 for AD1; ***p = 0.0004). c Representative confocal images of marker expression in the indicated hiBFCNs at 52 dpi. Scale bar, 10 μm. d Quantification of soma AT8 expression in the indicated hiBFCNs at 52 dpi (mean ± SEM; n = 66 for NL2; n = 41 for AD2; ns, not significant). e Representative confocal images of marker expression in the indicated hiBFCNs at 62 dpi. Scale bar, 10 μm. f Quantification of soma AT8 expression in the indicated hiBFCNs at 62 dpi (mean ± SEM; n = 39 for NL2; n = 25 for AD2; *p = 0.0298). g Representative confocal images of marker expression in the indicated hiBFCNs at 78 dpi. Scale bar, 10 μm. h Quantification of soma AT8 expression in the indicated hiBFCNs at 78 dpi (mean ± SEM; n = 50 for NL2; n = 30 for AD2; **p = 0.0078)

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