Fig. 5
From: A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease
Correlation analysis between three novel LOAD mouse models and human co-expression modules reveals age-related changes in immune function. a Correlation analysis highlights age-related changes in Trem2*R47H, APOE4 KI and APOE4 KI/Trem2*R47H mice. Circles correspond to significant (p < 0.05) positive (blue) and negative (red) Pearson’s correlation coefficients for gene expression changes in mice associated with distinct human co-expression modules. This includes multiple modules linked to immune function (Consensus Cluster B) and stress response (Consensus Cluster E). b Pathway analysis for the Reactome and WikiPathway resources highlights a significant enrichment (FDR adjusted p < 0.05) of pathways involved in complement activation in both older (10–14 months) APOE4 KI and Trem2*R47H mice. c Genes encoding for complement component C1q show an antagonistic transcriptional effect between the Trem2*R47H and APOE4 KI/Trem2*R47H mice when compared to the humanized APOE4 knock-in model (*denotes FDR adjusted p < 0.05)