Fig. 6
From: A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease
Platform comparison of how the Mouse AD Panel and RNA-Seq each correlate with the AMP-AD modules. Correlation coefficients for human AMP-AD co-expression modules and gene expression profiles derived from the RNA-Seq (x-axis), and the NanoString Mouse AD Panel for the same mouse samples (y-axis). Both data types were obtained from 137 samples, including three different ages and three mouse models carrying LOAD risk variants. a Strong positive correlations (p < 2.2 × 10− 16) were observed across all ages and samples combined when comparing expression of the 770 transcripts on the NanoString panel. b The correlation between NanoString and RNA-Seq expression analysis decreased overall when comparing all module transcripts measured by RNA-Seq to the subset of 770 probes on the NanoString panel. However, an age specific effect was observed for the mouse transcripts in which correlation with human co-expression modules increased with age (3–5 months p = 4.39 × 10− 8, 7–9 months p = 2.35 × 10− 8, 12–14 months p = 2.75 × 10− 13)