Fig. 2

Functional evaluations were made in C, D, pMCAo and pMCAo+D mice. a From D1 to D14, the pMCAo + D group had significantly lower neurological scores than C, D and pMCAo mice) (P < 0.0001). By D21, pMCAo + D mice had completely recovered and no significant differences between groups remained. b In the open field test, at D28, the total distance travelled by pMCAo+D mice was significantly less than that of C mice (P < 0.001) and also less for D mice than C mice (P < 0.001). c In the marble burying test, at D29, significantly fewer marbles were buried by pMCAo+D mice than by C mice (P < 0.01) and by D mice compared to C mice (P < 0.05). d There were no significant differences between the 4 groups in the splash test at D29. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001