Fig. 7

Astrocytic Clu overexpression ameliorates amyloid pathology and glial reactivity in 5xFAD mice. a Representative images of methoxy-X04 and 6E10 staining of 5xFAD mouse brains injected with GFP or Clu. Scale bar, 500 μm (insert 50 μm). b Quantification of X04 or 6E10 intensities, plaque numbers and plaque size. c Representative immunofluorescence images using anti-GFAP, -Iba-1 and -CD68 antibodies. Scale bar, 50 μm. d Quantification of immunointensitivites. e Representative anti-Lamp1 immunofluorescence images. f Quantification of Lamp1 immunoreactivities. n = 6/group. Scale bar, 500 μm, second from right; 50 μm, right for both (c) & (e). All data are presented as mean ± SEM. *p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001 (Student’s t test)