Fig. 1
From: Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
mTORC1 pathways. Growth factor/neurotrophin, energy, nutrient and oxygen tension state inputs are shown. Effects on protein synthesis, glucose transport, autophagy and cell growth/survival are indicated. PRAS and Deptor are negative C1 regulatory units. Caloric restriction/AMPK and amino acid restriction through TSC1/2 are important C1-inhibitory paths. Negative feedback onto insulin/PI3K/Akt from C1 is noted