Fig. 1

Impaired olfactory behavior in APP/PS1 and 3xTg mice. a Representative tracking paths in the cookie-finding test. b Illustration of buried-food test. c APP/PS1 mice showed significantly more entries into the wrong arms in the cookie-finding test compared to WT littermates (n = 16 for WT and 15 for APP/PS1, p = 0.02). d APP/PS1 mice spent significantly more time to find the food in the buried-food test (n = 10 for both WT and APP/PS1, p = 0.04). e Aged (11–12 months) APP/PS1 mice showed significantly more entries into the wrong arms (n = 12 for both WT and APP/PS1, p = 0.03). f Aged APP/PS1 mice showed significantly increased time spent in finding the food (n = 11 for both WT and APP/PS1, p = 0.0003). g-h 3xTg mice showed impaired olfactory behavior as well (n = 7 for WT and 3xTg, p = 0.04 for cookie-finding test and 0.03 for buried-food test). Values represent mean ± SEM. Two-sample t-test. *p < 0.05, *** p < 0.001