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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3

Fig. 3

High dose of AAV-HMOX1 causes photoreceptor degeneration. a Immunostaining of Recoverin (panels a') and GFAP (panels b') in the retinas from albino mice 2 weeks after infection with a low or a high dose of AAV8-HMOX1 virus. b, c Cell death analysis by TUNEL assay in retinas from albino mice under the indicated conditions b and the quantification of the TUNEL-positive cells in the photoreceptor cell layer of the mice c (Error bars: SD; n = 3, Student T-test). AAV-HMOX1 L, low dose of AAV-HMOX1; AAV-HMOX1 H, high dose of AAV-HMOX1; GCL:ganglion cell layer; INL:inner nuclear layer; ONL: outer nuclear layer; IS: photoreceptor inner segments; OS: photoreceptor outer segments; ns, no significant difference; *** indicates p < 0.001. Scale bars: 50 μm

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