Fig. 6

Os-pep restores LTP ability in the APP/PS1, Adipo^−/− and AβO-treated mice via AdipoR1 dependent manner. (a, panels (a-c); b, panels (a-c)) Upper trace, a representative EPSC trace before and after LTP was induced by paired stimuli in the CA1 regions of the hippocampi of Veh-injected WT or Veh-injected APP/PS1 and Adipo^−/− mice respectively. Lower trace, an average time course of EPSCs before and after LTP was induced by paired stimuli in the CA1 regions of the hippocampi of Veh-injected WT, APP/PS1 and Adipo^−/− mice, as well as Os-pep-treated APP/PS1 and Adipo^−/− mice. (a, panel (d); b, panel (d)) A summary of the effect of the Os-pep treatment on LTP induction in APP/PS1 and Adipo^−/− mice respectively. (c, panels (a-d)) Upper trace, a representative EPSC trace before and after LTP was induced by TBS stimuli in the CA1 regions of the hippocampi of Veh-injected WT or Veh-injected AβO. Lower trace, an average time course of EPSCs before and after LTP was induced by paired stimuli in the CA1 regions of the hippocampi of Veh-injected WT or Veh-injected AβO mice, as well as Os-pep-treated AβO-injected mice subjected to scramble shRNA and shRNA mediating silencing of AdipoR1 gene. (c, panel (e)) A summary of the effect of the Os-pep dosage on LTP induction in Veh-injected WT or Veh-injected AβO mice, as well as Os-pep-treated AβO mice subjected to scramble and shRNA mediating silencing of AdipoR1 gene. The data are expressed as the means ± SEM for n = 5–6 mice per group and the number of independent experiments = 3. Significance = *p < 0.05, **p < 0.01 ***p < 0.001; #p < 0.05, ##p < 0.01, ###p < 0.001; One-way ANOVA followed by Turkey’s post hoc test