From: Identification of sixteen novel candidate genes for late onset Parkinson’s disease
Series | N variants | PD cases (n = 394) | FPD (n = 172) | SPD (n = 222) | Cnt. (n = 203) | p | OR | 95%CI |
---|---|---|---|---|---|---|---|---|
MAF ≤ 0.001 | 0 | 197 (50.0%) | 82 (47.6%) | 115 (51.8%) | 135 (66.5%) | baseline | ||
1 | 129 (32.7%) | 53 (30.8%) | 76 (34.2%) | 54 (26.6%) | 0.014 | 1.6 | 1.1–2.4 | |
≥2 | 68 (17.3%) | 37 (21.6%) | 31 (13.9%) | 14 (6.8%) | 4.4 × 10−5 | 3.3 | 1.8–6.7 | |
MAF ≤ 0.001 including variants in GBA gene | 0 | 182 (46.2%) | 79 (45.9%) | 103 (46.4%) | 128 (63.0%) | baseline | ||
1 | 130 (33.2%) | 53 (30.8%) | 77 (35.1%) | 59 (29.0%) | 0.028 | 1.55 | 1.04–2.32 | |
≥2 | 82 (20.5%) | 40 (23.2%) | 42 (18.5%) | 16 (7.2%) | 3.4 × 10−6 | 3.59 | 1.97–6.90 |