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Table 2 Polygenic variant load in the Italian cohort

From: Identification of sixteen novel candidate genes for late onset Parkinson’s disease

Series N variants PD cases (n = 394) FPD (n = 172) SPD
(n = 222)
Cnt. (n = 203) p OR 95%CI
MAF ≤ 0.001 0 197 (50.0%) 82 (47.6%) 115 (51.8%) 135 (66.5%) baseline   
1 129 (32.7%) 53 (30.8%) 76 (34.2%) 54 (26.6%) 0.014 1.6 1.1–2.4
≥2 68 (17.3%) 37 (21.6%) 31 (13.9%) 14 (6.8%) 4.4 × 10−5 3.3 1.8–6.7
MAF ≤ 0.001
including variants in GBA gene
0 182 (46.2%) 79 (45.9%) 103 (46.4%) 128 (63.0%) baseline   
1 130 (33.2%) 53 (30.8%) 77 (35.1%) 59 (29.0%) 0.028 1.55 1.04–2.32
≥2 82 (20.5%) 40 (23.2%) 42 (18.5%) 16 (7.2%) 3.4 × 10−6 3.59 1.97–6.90
  1. MAF Minor allele frequency, PD Parkinson’s disease, FPD Familial PD cases, SPD Sporadic PD cases, Cnt Controls fromTSI, Tuscan Italian population, MNI cohort and Moli-sani genetic biobank, p p-value calculated with Fisher Exact Probability Test, OR Odds Ratio, CI Confidence interval