Fig. 3
Paired-pulse ratios of evoked excitatory postsynaptic currents are altered in an age-dependent manner in AppNL-F and AppNL-G-F mice. a) Examples of evoked CA3-CA1 EPSCs in response to paired stimuli applied to Schaffer collaterals in slices from 20-month-old animals. b) Paired-pulse ratios of CA3-CA1 EPSCs at ages indicated. Sample sizes (animals) are indicated by the numbers to the right of the 50 ms data points. Holm-Sidak post hoc tests compared to wild type are indicated by * p < 0·05; ** p < 0·01; **** p < 0·0001 (2-month-old: p = 0·0174; 7-month-old: p = 0·019; 9-months-old AppNL-F 25 ms p = 3·4 × 10−8, AppNL-G-F 25 ms p = 1·1 × 10−7, AppNL-F 50 ms p = 0·0086, AppNL-G-F 50 ms p = 0·021; 20-month-old AppNL-F 25 ms p = 7.5 × 10−5, AppNL-G-F 25 ms p = 6·0 × 10−9, AppNL-G-F 50 ms p = 0·0034). c) Failure rates of unitary evoked EPSCs in 20-month-old wild type and App knock-in animals. Holm-Sidak post hoc tests compared to wild type are indicated by * p < 0·05; ** p < 0·01 (NL-F p = 0·013, NL-G-F p = 0·0069). Data in panels B and C plotted as mean ± SEM. Sample sizes (animals) are indicated by the numbers within bars