Fig. 4
Altered locus of expression of long-term potentiation in AppNL-F and AppNL-G-F mice. a) Example CA3-CA1 fEPSPs recorded in stratum radiatum of slices from 9-month-old animals. b) Example time courses of field EPSP slope, expressed as percent of mean baseline and relative to induction tetanus. c) Summary of LTP magnitude across ages calculated as the mean of 51–60 min after conditioning. d) Paired-pulse ratio mean of 51–60 min after conditioning as a percentage of baseline. Data in panels C and D plotted as mean ± SEM. Sample sizes (animals) are indicated in the bars within panel C. NB, at 9 and 20 months, while the paired-pulse ratio was significantly different from baseline for both App knock-in lines and not for wild type, there was no significant difference between the groups (One sample t-tests versus 100%: * p < 0·05; ** p ≤ 0·01; 9-months-old AppNL-F p = 0·0080, AppNL-G-F p = 0·014; 20-months-old AppNL-F p = 0·049, AppNL-G-F p = 0·010)