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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: “Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies

Fig. 1

Schematic showing 2N4R tau (441 amino acids), the longest isoform expressed in human brain. Tau protein contains major structural domains including N-terminal domain with N1 and N2 inserts, proline rich region, four major microtubule-binding repeats (R1-R4), and C-terminal domain. The N1, N2 and R2 regions can be alternatively spliced in the human brain resulting in 6 isoforms: 0N3R, 1N3R, 2N3R, 0N4R, 1N4R, and 2N4R. The position of identified phosphorylation sites found in AD brains are shown [1,2,3,4,5]

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Molecular Neurodegeneration

ISSN: 1750-1326