Table 1 List of phosphorylation sites found in brain and CSF from AD patients versus healthy controls. Phosphorylation sites found in brains of AD and age-matched controls were based on mass spectrometry studies that isolated PHF-tau [1,2,3,4,5]. Fewer studies have attempted to map phosphorylated tau within the CSF of AD and age-matched controls [62, 63]. *Tyr18 has been identified in immunocytochemical staining, but not detected by mass spectrometry

Tyr18

X*

X*

Tyr29

X

Thr30

X

Thr39

X

Ser46

X

X

X

X

Ser56

X

Ser61

X

X

Ser68

X

Thr69

X

Thr71

X

Thr102

X

Thr111

X

X

X

Ser113

X

X

Thr153

X

X

Thr175

X

X

Thr181

X

X

X

X

Ser184

X

X

Ser185

X

Ser191

X

Ser198

X

X

Ser199

X

X

X

X

Ser202

X

X

X

X

Thr205

X

X

X

Ser208

X

X

X

Ser210

X

Thr212

X

X

Ser214

X

X

X

X

Thr217

X

X

X

X

Thr220

X

Thr231

X

X

X

Ser235

X

X

X

X

Ser237

X

Ser238

X

X

X

Ser241

X

Ser258

X

X

X

Ser262

X

X

X

X

Thr263

X

Ser285

X

Ser289

X

X

Ser293

X

Ser305

X

Tyr310

X

Ser316

X

Ser352

X

Ser356

X

Thr361

X

Thr386

X

Tyr394

X

Ser396

X

X

X

X

Ser400

X

X

X

Thr403

X

X

X

Ser404

X

X

X

Ser409

X

Ser412

X

X

Ser413

X

X

Thr414

X

X

Ser416

X

X

Ser422

X

Ser433

X

Ser435

X