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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

Fig. 1

Saposin proteins are enriched in DNs surrounding Aβ plaques in AD brains. A Fixed brain sections from 6-month-old APPNL-G-F, 4-month-old 5xFAD, and 8-month-old APP-PS19delE9 (PA) mice co-stained with thioflavin-S (Thio-S) or 6E10 and specific antibodies to the lysosomal proteins SAP-C, SAPs, or LAMP1. B AD postmortem brain sections were co-stained with  6E10 and SAPs or Thio-S and SAP-C or Cath-D antibodies. Scale bar is shown at the right bottom of each panel

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Molecular Neurodegeneration

ISSN: 1750-1326