Fig. 2
From: Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology
Approaches to explore the composition and organization of senile plaques. (A) Top-down methods starts from plaque tissue samples and analyze the plaque structure by e.g. microscopy or mass-spectrometry proteomics. (B) Bottom-up methods make use of in vitro models in order to study composition, protein structure and interactions from a molecular perspective. The amyloid corona refers to the layer of proteins from a biological fluid that is sequestered by the amyloid fibrils