AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma

Table 1 Dendritic parameters

Group	Treatment	Total dendritic lenght (μm) (mean ± SEM)	Dendritic field area (μm²) (mean ± SEM)	Number dendritic branches (mean ± SEM)	Number of animals (N)	Number of RGC (n)
Sham	–	4517 ± 154	134,899 ± 8638	97 ± 3	6	51
OHT	Vehicle	3511 ± 190	97,523 ± 7968	74 ± 3	6	40
OHT	CC	4189 ± 215	126,581 ± 11,024	92 ± 5	4	30
OHT	siCTL	2990 ± 140	83,969 ± 5709	78 ± 2	5	33
OHT	siAMPK	3910 ± 106	121,583 ± 7879	90 ± 3	5	33
OHT	siAMPK+Veh	4336 ± 122	136,330 ± 10,135	97 ± 2	4	32
OHT	siAMPK+Rapa	2454 ± 142	73,897 ± 7042	61 ± 3	4	41
Sham	Compound C	4432 ± 191	141,243 ± 9226	95 ± 5	4	28
Sham	Rapamacyn	4341 ± 201	128,375 ± 7467	94 ± 6	3	28
Sham	siAMPK	4253 ± 195	129,883 ± 10,928	94 ± 4	3	33

ISSN: 1750-1326