From: Cellular and pathological heterogeneity of primary tauopathies
Tauopathy | Tau lesions | |||
---|---|---|---|---|
Disorder | Predominant tau isoform | Neuron | Astrocyte | Oligodendrocyte |
PiD | 3R | Pick bodies (+++) and Ballooned neurons (++) | Ramified astrocytes | Pick body-like inclusions |
PSP | 4R | Neurofibrillary tangles (++) and Pretangles (+++) | Tufted astrocytes | Coiled bodies(+++) |
CBD | 4R | Pretangles (+++) and Ballooned neurons(++) | Astrocytic plaques | Coiled bodies(++) |
GGT | 4R | Pretangles (+++) | Globular astrocytic inclusions | Globular oligodendroglial inclusions |
AGD | 4R | Grains (+++) and Ballooned neurons(+) | Ramified (bushy) astrocytes | Coiled bodies(+) |
PART | 3R/4R | Neurofibrillary tangles | N/A | N/A |
ARTAG | 4R | N/A | Thorn-shaped and Granular fuzzy astrocytes | N/A |
AD | 3R/4R | Neurofibrillary tangles (+++) | N/A | N/A |
CTE | 3R/4R | Neurofibrillary tangles (++) | Thorn-shaped astrocytes | N/A |