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Table 1  A list of different tauopathies and their cell type-specific tau lesions

From: Cellular and pathological heterogeneity of primary tauopathies

Tauopathy

Tau lesions

Disorder

Predominant tau isoform

Neuron

Astrocyte

Oligodendrocyte

PiD

3R

Pick bodies (+++) and Ballooned neurons (++)

Ramified astrocytes

Pick body-like inclusions

PSP

4R

Neurofibrillary tangles (++) and Pretangles (+++)

Tufted astrocytes

Coiled bodies(+++)

CBD

4R

Pretangles (+++) and Ballooned neurons(++)

Astrocytic plaques

Coiled bodies(++)

GGT

4R

Pretangles (+++)

Globular astrocytic inclusions

Globular oligodendroglial inclusions

AGD

4R

Grains (+++) and Ballooned neurons(+)

Ramified (bushy) astrocytes

Coiled bodies(+)

PART

3R/4R

Neurofibrillary tangles

N/A

N/A

ARTAG

4R

N/A

Thorn-shaped and Granular fuzzy astrocytes

N/A

AD

3R/4R

Neurofibrillary tangles (+++)

N/A

N/A

CTE

3R/4R

Neurofibrillary tangles (++)

Thorn-shaped astrocytes

N/A

  1. Abbreviations: +: mild; ++: moderate; +++: marked; N/A not applicable