Skip to main content

Table 1  A list of different tauopathies and their cell type-specific tau lesions

From: Cellular and pathological heterogeneity of primary tauopathies

Tauopathy Tau lesions
Disorder Predominant tau isoform Neuron Astrocyte Oligodendrocyte
PiD 3R Pick bodies (+++) and Ballooned neurons (++) Ramified astrocytes Pick body-like inclusions
PSP 4R Neurofibrillary tangles (++) and Pretangles (+++) Tufted astrocytes Coiled bodies(+++)
CBD 4R Pretangles (+++) and Ballooned neurons(++) Astrocytic plaques Coiled bodies(++)
GGT 4R Pretangles (+++) Globular astrocytic inclusions Globular oligodendroglial inclusions
AGD 4R Grains (+++) and Ballooned neurons(+) Ramified (bushy) astrocytes Coiled bodies(+)
PART 3R/4R Neurofibrillary tangles N/A N/A
ARTAG 4R N/A Thorn-shaped and Granular fuzzy astrocytes N/A
AD 3R/4R Neurofibrillary tangles (+++) N/A N/A
CTE 3R/4R Neurofibrillary tangles (++) Thorn-shaped astrocytes N/A
  1. Abbreviations: +: mild; ++: moderate; +++: marked; N/A not applicable