Fig. 5
From: Functional microRNA targetome undergoes degeneration-induced shift in the retina
Pathway enrichment of differentially bound AGO2 mRNA in PD retinas. (A) Up-regulated AGO2-bound mRNA were analysed for GO biological process enrichment with significant terms clustered with REVIGO for visual analysis. (B) The same process was performed for down-regulated genes in PD retinas. (C) Gene set enrichment analysis (GSEA) was performed using a ranked list of the differentially AGO2-bound mRNAs against the C2 database for enriched pathways. Selected pathways were separated into four groups: cell death and motility; stress response visual transduction; and immune response (P < 0.05). Numbers accompanying the bars represent the number of genes associated with the respective pathway