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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy

Fig. 1

Redox imbalance in OS. An increased production of oxidants (ROS, RNS, and RSS) and a dysfunction, mostly a decrease, in the antioxidant system (Enzymatic, Non-enzymatic, and Dietary antioxidants) result in damage to cells and can contribute to the pathogenesis and progression of many neurodegenerative diseases, including ALS. ROS: reactive oxygen species, RNS: reactive nitrogen species, RSS: reactive sulfur species. •Refers to an unpaired electron; R and R' represent functional groups ≠ H

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Molecular Neurodegeneration

ISSN: 1750-1326