Skip to main content
Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy

Fig. 3

Domain architecture of the human KEAP1 (a) and NRF2 (b) proteins. Functional domains, relevant motifs (3-box, DLG, ETGE, DSGIS, DSAPGS), and the most important cysteine residues (C151, C273, C288) involved in stress sensing are indicated. BTB: Broad complex/Tramtrack/Bric à Brac, IVR: intervening region, DGR: double glycine region, Neh1–7: NRF2-ECH homology 1–7

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326