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Table 2 Neuron control vs LOAD differential peaks overlapped with 25 LOAD-GWAS regions as well as female glia control vs LOAD differential peaks overlapped with 25 LOAD-GWAS regions. For each panel, upper: more open in LOAD; lower: less open in LOAD

From: Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains

Neuron control vs. LOAD differential peaks overlapped with 25 LOAD-GWAS regions
Differential sites with FDR < 0.05 Peak call GWAS ± 100 kb Gene SNP SNP Position
More accessible in LOAD
chr6:32551592-32552707 chr6:32475406-32675406 HLA-DRB1 Rs9271058 chr6:32575406
chr6:32489394-32490069 chr6:32475406-32675406 HLA-DRB1 Rs9271058 chr6:32575406
Less accessible in LOAD
chr20:54994099-54994641 chr20:54897568-55097568 CASS4 Rs6024870 chr20:54997568
chr8:27209401-27210247 chr8:27119987-27319987 PTK2B Rs73223431 chr8:27219987
chr8:27563212-27563671 chr8:27367686-27567686 CLU Rs9331896 chr8:27467686
Female glia control vs. LOAD differential peaks overlapped with 25 LOAD-GWAS regions
Differential sites with FDR < 0.05 Peak call GWAS ± 100 kb Gene SNP SNP Position
More accessible in LOAD
chr10:11784165-11784736 chr10:11620308-11820308 ECHDC3 Rs7920721 chr10:11720308
Less accessible in LOAD
chr14:92966426-92967442 chr14:92832828-93032828 SLC24A4 Rs12881735 chr14:92932828
chr16:19894588-19895301 chr16:19708163-19908163 IQCK Rs7185636 chr16:19808163
chr17:61627113-61628372 chr17:61438148-61638148 ACE Rs138190086 chr17:61538148
chr19:1101756-1102160 chr19:956492-1156492 ABCA7 Rs3752246 chr19:1056492
chr19:45416036-45416558 chr19:45311941-45511941 APOE Rs429358 chr19:45411941
chr19:45428555-45429362 chr19:45311941-45511941 APOE Rs429358 chr19:45411941
chr19:45454352-45455071 chr19:45311941-45511941 APOE Rs429358 chr19:45411941
chr7:100025783-100028055 chr7:99991795-100191795 NYAP1 (ZCWPW1) Rs12539172 chr7:100091795