Table 2 Neuron control vs LOAD differential peaks overlapped with 25 LOAD-GWAS regions as well as female glia control vs LOAD differential peaks overlapped with 25 LOAD-GWAS regions. For each panel, upper: more open in LOAD; lower: less open in LOAD
Neuron control vs. LOAD differential peaks overlapped with 25 LOAD-GWAS regions | |||||
Differential sites with FDR < 0.05 | Peak call | GWAS ± 100 kb | Gene | SNP | SNP Position |
More accessible in LOAD | |||||
chr6:32551592-32552707 | chr6:32475406-32675406 | HLA-DRB1 | Rs9271058 | chr6:32575406 | |
chr6:32489394-32490069 | chr6:32475406-32675406 | HLA-DRB1 | Rs9271058 | chr6:32575406 | |
Less accessible in LOAD | |||||
chr20:54994099-54994641 | chr20:54897568-55097568 | CASS4 | Rs6024870 | chr20:54997568 | |
chr8:27209401-27210247 | chr8:27119987-27319987 | PTK2B | Rs73223431 | chr8:27219987 | |
chr8:27563212-27563671 | chr8:27367686-27567686 | CLU | Rs9331896 | chr8:27467686 | |
Female glia control vs. LOAD differential peaks overlapped with 25 LOAD-GWAS regions | |||||
Differential sites with FDR < 0.05 | Peak call | GWAS ± 100 kb | Gene | SNP | SNP Position |
More accessible in LOAD | |||||
chr10:11784165-11784736 | chr10:11620308-11820308 | ECHDC3 | Rs7920721 | chr10:11720308 | |
Less accessible in LOAD | |||||
chr14:92966426-92967442 | chr14:92832828-93032828 | SLC24A4 | Rs12881735 | chr14:92932828 | |
chr16:19894588-19895301 | chr16:19708163-19908163 | IQCK | Rs7185636 | chr16:19808163 | |
chr17:61627113-61628372 | chr17:61438148-61638148 | ACE | Rs138190086 | chr17:61538148 | |
chr19:1101756-1102160 | chr19:956492-1156492 | ABCA7 | Rs3752246 | chr19:1056492 | |
chr19:45416036-45416558 | chr19:45311941-45511941 | APOE | Rs429358 | chr19:45411941 | |
chr19:45428555-45429362 | chr19:45311941-45511941 | APOE | Rs429358 | chr19:45411941 | |
chr19:45454352-45455071 | chr19:45311941-45511941 | APOE | Rs429358 | chr19:45411941 | |
chr7:100025783-100028055 | chr7:99991795-100191795 | NYAP1 (ZCWPW1) | Rs12539172 | chr7:100091795 | |