Fig. 2

Loss of L-DL in the hippocampus leads to cognitive deficits in mice. a, b L-DL knockdown efficiency in the hippocampus, as determined by immunoblotting (a) and densitometric analyses in (b). c-f The Morris water maze task. c Time of escape latency to the hidden platform was plotted for each spatial learning day (n = 15 mice per group). The frequency of crossing the target quadrant (d) and time spent in the target quadrant (e) in the probe trial (n = 15 mice per group). f The representative escape routes for control and L-DL KD mice in the probe trial. g Discrimination index for the object recognition test (n = 15 mice per group). h, i In the open field task, time spend in the center of the compartment (h) and total distance travelled (i) for control and L-DL KD mice (n = 15 mice per group). Statistical analysis was performed using by ANOVA or two-tailed Student’s t-test; * P < 0.05, ** P < 0.01, *** P < 0.001; error bars denote SEM