Fig. 7
From: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
Exacerbation of Microgliosis in αSyn PFF-seeded dTg mice. A Representative images showing IHC using antibodies specific for Iba1 to compare nTg, M20, L85, and dTg mice injected with PBS or αSyn PFFs at 8 (2 m.p.i.) and 10 months (4 m.p.i.) of age as indicated, and corresponding heatmap depicting regional Iba1 percent positivity. The increase in microglial proliferation is illustrated by the color change from blue (minimum of Iba1 percent positivity) to orange (maximum of Iba1 percent positivity). Gray indicates regions were not quantified during this study. B Quantitation of Iba1 percent positivity comparing the retrosplenial cortex, CA1 of the hippocampus, and the entorhinal cortex within each cohort. Two-Way ANOVA followed by Holm-Sidak’s multiple comparisons test was used for statistical analysis (n = 8,8,13; 6,8,12; 8,8,10; 6,8,11). Data are presented as mean +/− SEM. Scale bar: 500 μm