Fig. 8
From: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
Microglial Activation Increases in a Parallel Pattern Across Regions and Follows Escalation of αSyn and Aβ Pathology. A Representative high magnification images showing IHC using antibodies specific for Iba1, to compare regional microglial activation in nTg, M20, L85, and dTg mice injected with PBS or αSyn PFFs at 8 (2 m.p.i.) and 10 months (4 m.p.i.) of age as indicated. B Quantitation of Iba1 percent positivity comparing the retrosplenial cortex, CA1 of the hippocampus, and the entorhinal cortex between each cohort. Two-Way ANOVA followed by Holm-Sidak’s multiple comparisons test (n = 8,8,13; 6,8,12; 8,8,10; 6,8,11). Data are presented as mean +/− SEM. Scale bar: 50 μm