Fig. 5

Correlates of mitochondrial health demonstrate complex relationship with AD-related traits in the DLPFC. (A) Heatmap shows pairwise Pearson correlations between scores for the abundance of mitochondrial complexes I to V, mitochondrial content, and mtDNA-encoded proteins derived from mass spectrometry data, amyloid and tau derived from immunohistochemistry data, proportion of neurons derived from RNA-seq data, cognitive function, age, mtDNA heteroplasmy levels and mtDNAcn. Nonparanormal transformation was applied to mtDNA heteroplasmic mutation counts before calculating correlations. Number of available cases for each pair of variables is given in Fig. S4B. (B) Graph shows a sparse representation of the partial correlations between the different variables. An edge in this graph indicates that the two connected variables are correlated with each other after controlling for all other variables in the graph. Thickness and color of the edges represent the strength and direction of the partial correlation