Fig. 7

The single-cell analysis of SnG signatures in four different tissues. a Enrichment of the 51 conserved SnGs in the cell-type specific marker gene signatures in four tissues. For each tissue, the y-axis shows the cell types identified from the scRNA-seq data, and the x-axis represents the enrichment significance. The dotted line indicates the significance cutoff (aFETp = 0.01). b The violin plot showing SnGs that are preferentially expressed in the ductal cells of the pancreas. c The cell communication network between the ductal cells and other cell types in the pancreas. Cell communication was calculated by the observed ligand-receptor pairs between the sender (ductal) cell type and the receiver cell types. The links in the network plot indicate the significant ligand-receptor interactions (p < 0.05, 10,000 permutations) between any two cell types. The line thickness is proportional to the number of ligand-receptor pairs