Fig. 1

MRV infects the CNS and elicits a peripheral and central inflammatory response in 5XFAD mice. A Schematic of experimental paradigm. B, C, Copies/mL of MRV DNA B and ORF69 RNA C in cortex of 5XFAD mice infected with mock or MRV 7 dpi (i.p.). D, E,  Flow cytometry of absolute number of CD45⁺CD19⁻NKp46⁻ CD4⁺ or CD8⁺ thymocytes D and CD45⁺CD19⁻NKp46⁻CD3⁺ CD4⁺ or CD8⁺ T cells in the spleen E. F Inflammatory gene expression changes in cortical tissue. *P < 0.05 between WT mock and 5XFAD MRV. DP: CD4⁺CD8⁺ double positive. DN: CD4⁻CD8⁻ double negative. ø represents below levels of detection. Dpi: days post infection. Data expressed as mean ± SD, one-way ANOVA with Tukey’s post hoc test (two-sided) (b, c, d, e, f). P < 0.05. ns = not statistically significant. No other statistical comparisons are significant unless indicated