Fig. 4

IAPP-Tau PFFs promote the propagation of tau pathology in vivo. a, b Representative images of AT8 p-tau pathology in tissue sections (anterior hippocampal level) from the hippocampus, dentate gyrus, retrosplenial cortex, and entorhinal cortex of tau P301S mice 1 month (a) and 3 months (b) after the injection of PBS, tau PFFs or IAPP-tau PFFs. Scale bar, 200 μm in (a) and (b) upper panel, 50 μm in (a) and (b) lower panels. c-j Quantification of p-tau pathology of ipsilateral and contralateral sides in the hippocampus (c, d), dentate gyrus (e, f), entorhinal cortex (g, h), and retrosplenial cortex (i, j). n = 4 mice per group. Data are presented as means ± SEM. One-way ANOVA followed by Tukey’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001, n.s. not significant