Table 2 The activated microglia cluster exhibits similar transcriptional responses in previous gene sets of activated microglia
Gene Set | Description | Citation | Activated vs Homeostatic Adj_P-value | Interferon VS Homeostatic ADJ_P-Value |
|---|---|---|---|---|
Resting Microglia | Genes marking parenchymal microglia versus other brain myeloid cells | Friedman et al., 2018 | 6.24E-29 | 9.39E-03 |
Neurodegeneration | Genes upregulated in microglia across multiple neurogenerative disease models | Friedman et al., 2018 | 8.88E-49 | 7.21E-02 |
Interferon-related | Interferon-stimulated genes highly induced in response to virus | Friedman et al., 2018 | 1.00E+ 00 | 1.65E-15 |
Keren-Shaul DAM UP | Genes upregulated by disease-associated microglia (DAM) in a 5XFAD model of Amyloidosis | Keren-Shaul et al., 2017 | 7.93E-23 | 1.00E+ 00 |
Keren-Shaul DAM Down | Genes downregulated by DAM in a 5XFAD model of Amyloidosis | Keren-Shaul et al., 2017 | 9.93E-56 | 1.71E-05 |
Mathys Late-respone UP | Genes upregulated in the late-response microglia cluster of a CK-p25 mouse model of neurodegeneration | Mathys et al., 2017 | 2.17E-23 | 5.53E-08 |
Mathys Late-response DOWN | Genes downregulated in the late-response microglia cluster | Mathys et al., 2017 | 8.46E-74 | 1.79E-14 |
Hammond IRM | Genes upregulated by injury response microglia (IRM) in mice in response to a demyelinated lesion | Hammond et al., 2019 | 9.11E-07 | 9.24E-06 |