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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

Fig. 1

TREM2 regulates microglial cholesterol metabolism and participates in the response to myelin damage. The activation of the TREM2-DAP12 signaling pathway may promote microglial cholesterol efflux and reduces intracellular cholesterol to be stored as CE, possibly by activating PLCγ2. The effluent cholesterol might be carried by APOE-containing lipoproteins. Besides, TREM2 mediates the microglial response to myelin damage, leading to increased phagocytosis of myelin debris and thus may promote remyelination.

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Molecular Neurodegeneration

ISSN: 1750-1326