Table 2 H1 sub-haplotypes associated with PD susceptibility

H1.1

H1.1a

ACTCT

0.25 (0.26/0.24)

1

-

0.21 (0.2/0.23)

1

-

1

-

-

1

-

-

H1.1b

ACTTG

0.27 (0.38/0.22)

1.6

(1.45–1.78)

2.04E-19***

0.38 (0.39/0.36)

1.26

(1.09–1.46)

2.0E-03**

1.43

(1.13–1.81)

7.06

(0.0079)

3.0E-03**

1.48

(1.36–1.61)

7.06

(0.0079)

0***

H1.1c

GCCTG

0.18 (0.09/0.23)

0.37

(0.32–0.42)

1.3E-49***

0.14 (0.13/0.16)

0.96

(0.79–1.15)

6.40E-01

0.59

(0.23–1.52)

67.79

(< 0.0001)

2.70E-01

0.51

(0.46–0.57)

67.85 (< 0.0001)

0***

H1.1d

ATCTG

0.18 (0.06/0.24)

0.22

(0.19–0.26)

6.5E-92***

0.23 (0.24/0.21)

1.29

(1.1–1.52)

2.0E-03**

0.54

(0.1–3.01)

231.51

(< 0.0001)

4.90E-01

0.49

(0.44–0.55)

232.74 (< 0.0001)

0***

H1.1e

ACCTG

0.12 (0.21/0.08)

2.51

(2.2–2.86)

2.4E-45***

0.02 (0.02/0.02)

1.45

(0.98–2.17)

5.70E-02

1.97

(1.15–3.36)

7.13

(0.0079)

1.3E-02*

2.37

(2.1–2.68)

7.13

(0.0076)

0***

H1.2

H1.2a

TTTCGATG

0.48 (0.44/0.5)

1

-

0.49 (0.49/0.48)

1

-

1

-

-

1

-

-

H1.2b

TCTCGATG

0.17 (0.18/0.16)

1.27

(1.14–1.4)

2.02E-05***

0.17 (0.17/0.18)

0.93

(0.8–1.09)

3.56E-01

1.09

(0.81–1.47)

10.57

(0.001)

5.70E-01

1.14

(1.04–1.24)

10.58

(0.0011)

3.0E-03**

H1.2c

TTAAAATA

0.15 (0.16/0.14)

1.31

(1.16–1.47)

4.52E-06***

0.19 (0.21/0.18)

1.12

(0.97–1.3)

1.21E-01

1.22

(1.05–1.42)

2.65

(0.103)

9.0E-03**

1.23

(1.13–1.35)

2.65

(0.1037)

4.41E-06***

H1.2d

TTAAGATG

0.07 (0.08/0.06)

1.36

(1.16–1.59)

1.2E-04***

0.04 (0.03/0.05)

0.52

(0.38–0.69)

3.46E-06***

0.84

(0.33–2.19)

35.25

(< 0.0001)

7.27E-01

1.07

(0.94–1.23)

35.28 (< 0.0001)

2.90E-01

H1.2e

CTTCGATG

0.06 (0.06/0.06)

1.17

(0.99–1.39)

5.64E-02

0.08 (0.08/0.08)

1.05

(0.85–1.3)

6.76E-01

1.12

(0.99–1.28)

0.72

(0.40)

7.00E-02

1.12

(0.99–1.28)

0.72

(0.397)

7.00E-02

H1.2f

TTTCGGTG

0.05 (0.05/0.05)

1.16

(0.96–1.39)

1.18E-01

0.02 (0.02/0.03)

0.58

(0.41–0.83)

7.1E-03**

0.83

(0.42–1.64)

12.41

(0.0004)

6.00E-01

0.99

(0.84–1.16)

12.41

(0.0004)

9.10E-01

H1.2 g

TTAAAATG

0.01 (0.01/0.01)

1.1

(0.77–1.54)

6.07E-01

-

-

-

-

-

-

-

-

-

H1.2 h

TTTCGACG

0.01 (0.01/0.01)

1.28

(0.89–1.84)

1.64E-01

-

-

-

-

-

-

-

-

-

H1.3

H1.3a

GACTGAGAT

0.28 (0.32/0.27)

1

-

0.32 (0.32/0.32)

1

-

1

-

-

1

-

-

H1.3b

CATTAGGGC

0.18 (0.11/0.22)

0.43

(0.38–0.49)

1.66E-41***

0.18 (0.18/0.19)

0.95

(0.81–1.11)

5.22E-01

0.64

(0.29–1.44)

58.53

(< 0.0001)

2.80E-01

0.57

(0.52–0.63)

58.57 (< 0.0001)

0***

H1.3c

GATTGAGAT

0.17 (0.21/0.16)

1.11

(0.99–1.24)

7.37E-02

0.16 (0.16/0.17)

0.95

(0.80–1.12)

5.33E-01

1.04

(0.89–1.21)

2.24

(0.134)

6.10E-01

1.06

(0.96–1.16)

2.24

(0.1343)

0.23

H1.3d

CTTTGGTGC

0.15 (0.12/0.16)

0.61

(0.54–0.7)

1.58E-14***

0.2 (0.21/0.18)

1.16

(0.99–1.36)

5.81E-02

0.84

(0.45–1.56)

35.27

(< 0.0001)

5.80E-01

0.77

(0.7–0.85)

35.28 (< 0.0001)

2.96E-07***

H1.3e

CATTGGGGC

0.09 (0.14/0.07)

1.67

(1.45–1.92)

2.79E-13***

0.02 (0.02/0.02)

0.81

(0.54–1.21)

2.83E-01

1.19

(0.58–2.42)

12.01

(0.0004)

6.30E-01

1.54

(1.35–1.75)

12.01

(0.0005)

4.57E-11***

H1.3f

CATTGGGGT

0.08 (0.07/0.09)

0.6

(0.51–0.70)

9.34E-11***

0.09 (0.1/0.08)

1.15

(0.93–1.42)

2.00E-01

0.81

(0.44–1.5)

21.37

(< 0.0001)

5.10E-01

0.74

(0.66–0.84)

21.38 (< 0.0001)

3.59E-06***

H1.3 g

GATCGAGAT

0.04 (0.04/0.04)

0.83

(0.67–1.03)

9.39E-02

0.03 (0.02/0.02)

0.55

(0.38–0.78)

5.58E-04***

0.7

(0.49–1.02)

3.48

(0.062)

6.60E-02

0.75

(0.63–0.9)

3.48 (0.062)

1.6E-03**