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Table 1 Interacting receptors with apoE and CNS cell types in which they can be expressed

From: APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Receptors interacting with apoE

CNS cell-type

SORLA (SORL1, LR11)

Microglia [154], Neurons [155, 156]

VLDLR

Astrocytes, microglia, oligodendrocytes, pyramidal neurons, neuroblasts, glioblasts, Cajal-Retzius cells [123]

ApoER2 (LRP8)

Granule cells of dentate gyrus, piramidal cells [123]

LDLR

Astrocytes, neurons, oligodendrocytes [157, 158]

LRP1

Neurons, astrocytes, microglia, [159, 160]

LRP2 (Megalin)

Oligodendrocytes [161], astrocytes [162], neurons [163]

LRP4 (MEGF7)

Astrocytes, oligodendrocytes, microglia [164], neurons [165]

LRP5

Microglia [166], astrocytes [167], neurons [168]

LRP6

Microglia [166], astrocytes [169], neurons [170]

TREM2

Microglia [171], dendritic cells [172], astrocytes [173]

TLR4

Microglia [174], astrocytes [173], neurons [175]

  1. Results retrieved from human, animal and in vitro studies. () Other names by which the receptor is also known
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Molecular Neurodegeneration

ISSN: 1750-1326