APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Table 2 Described binding affinities of the apoE isoforms to the lipoprotein-binding receptors LDLR, LRP1, VLDLR, and the endocytic receptor SORLA

Receptor	Binding affinity			Highest binding affinity to
Receptor	apoE2	apoE3	apoE4	Highest binding affinity to
LDLR	↓↓	↑↑	↑↑	Lipidated apoE particles [119]
LRP1	↓	↑	↑	Recombinant apoE and apoE aggregates [119]
VLDLR	-	-	-	Lipid-free apoE [118]
SORLA/LR11	↓	-	↑	Not well defined [156]

SORLA presents common structural features with the LDL receptor family. (-) no differences observed between apoE isoforms, ↑ (high), ↑↑ (higher), ↓ (low), ↓↓ (very low)

ISSN: 1750-1326