Table 1 Summary of tau interactome studies and localized proteomics studies of tau aggregates
From: Tau interactome and RNA binding proteins in neurodegenerative diseases
Study | Species | Model | TYPE OF STUDY | Tau Target | Replicates |
|---|---|---|---|---|---|
Ayyadevara et al., 2016Â [12] | Human | Post-mortem brain tissue | Interactome | Total tau (tau-5) | 4 AD, 4 Control |
Drummond et al., 2020Â [30] | Human | Post-mortem brain tissue | Interactome | PHF1 tau | 5 AD |
Hsieh et al., 2019Â [54] | Human | Post-mortem brain tissue | Interactome | Total tau (tau-5) | 4 AD, 4 Control |
Meier et al., 2015Â [82] | Human | Post-mortem brain tissue | Interactome | Total tau (tau-5) | 3 AD, 3 Control |
Gunawardana et al., 2015Â [48] | Human | SHSY5Y cells | Interactome | Full length tagged tau | 3 replicates |
Tracy et al., 2022Â [105] | Human | Human IPSC derived excitatory neurons | Interactome | Full length tagged tau and (WT, V337M and P301L) | 7 replicates WT tau, 8 replicates V337M and P301L tau |
Wang et al., 2019Â [110] | Human | IMR-31 and ReN VM cells | Interactome | 3R, 4R or 4RP301L GFP tau constructs | 3 replicates |
Jiang et al., 2021Â [57] | Mouse | C5Bl6/J Primary Neurons | Interactome | 4R1N-tau:mCherry:Cry2Olig construct | 3 replicates 4R1N-tau:mCherry:Cry2Olig construct, 3 replicates mCherry:Cry2Olig construct |
Liu et al., 2016 [71] | Mouse | C5Bl6/J and Tau KO | Interactome | Total tau, 0 N, 1 N and 2 N tau | 3 total tau, 1 each of 0 N, 1 N and 2 N tau |
Maziuk et al., 2018Â [79] | Mouse | rTg4510, PS19 and TIA1-/- C5Bl6/J | Interactome | Total tau (tau-13) | 4 rtg4510, 4 C57BL6/J |
Sinsky et al., 2020Â [99] | Rat | Humanised tau | Interactome | Total tau (DC18, DC190 and DC25 tau) | 2 transgenic, 2 control |
Wang et al., 2017Â [109] | Mouse | PS19 | Interactome | Total tau (tau-5, tau-21, tau-24) | 4 replicates |
Hondius et al., 2021Â [52] | Human | Post-mortem brain tissue | Localized proteomics | GVD and NFT positive neurons | 12 AD, 12 Control, 3000 neurons per sample |
Drummond et al., 2020Â [30] | Human | Post-mortem brain tissue | Localized proteomics | NFT pathology | 7 AD, 4000 NFTs per sample |
Wang et al., 2005 [112] | Human | Post-mortem brain tissue | Localized proteomics | NFT pathology | 4 AD, ~ 2000 total NFTs |