Table 2 Summary of tau interacting HNRNPs and select disease associated RNA binding proteins from human studies
From: Tau interactome and RNA binding proteins in neurodegenerative diseases
RBP | Number of Studies | pTau Interactor | APEX tagged | Interacts with Mutant Tau | Present in NFT | Altered in GVD Neurons | Altered in NFT Neurons | Interacts with Mutant Tau |
|---|---|---|---|---|---|---|---|---|
HNRNPK | 4 | Yes | No | Yes | Yes | No (Increased) | No | Yes |
HNRNPA1 | 4 | Yes | Yes | Yes | Yes | No (Increased) | No | Yes |
HNRNPA2B1 | 4 | Yes | No | Yes | Yes | No (Increased) | No | Yes |
HNRNPA3 | 4 | No | No | Yes | Yes | No | No (Decreased) | Yes |
HNRNPA0 | 3 | No | No | Yes | No | No | No (Decreased) | Yes |
HNRNPC | 3 | No | No | Yes | Yes | No | No | Yes |
HNRNPD | 3 | No | No | Yes | Yes | No | Yes (Decreased) | Yes |
HNRNPM | 3 | No | No | Yes | Yes | No (Decreased) | Yes (Decreased) | Yes |
HNRNPR | 3 | No | No | Yes | Yes | No | Yes (Decreased) | Yes |
HNRNPU | 3 | No | No | Yes | Yes | Yes (Decreased) | Yes (Decreased) | Yes |
PTBP1 | 4 | No | No | Yes | No | No | No | Yes |
FUS | 3 | No | No | Yes | Yes | No | Yes (Decreased) | Yes |
SFPQ | 3 | No | No | Yes | Yes | No | No (Increased) | Yes |
G3BP1 | 3 | No | No | Yes | No | No | NA | Yes |
NONO | 3 | No | No | Yes | Yes | No | NA | Yes |
PABPC1 | 3 | No | Yes | Yes | Yes | No | NA | Yes |
TARDBP | 1 | No | No | Yes | Yes | Yes (Decreased) | Yes (Decreased) | Yes |
TIA1 | N.D | N.D | N.D | N.D | N.D | N.D | N.D | N.D |