Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease

Table 1 Reported changes in transcriptional and/or protein levels of neurotrophin signaling components exhibited by AD patients

*NEUROTROPHIN SIGNALING*	*EXPRESSION LEVELS IN AD PATIENTS*
*NEUROTROPHIN SIGNALING*	Upregulation	Downregulation
proNGF	↑ in brain [59, 62,63,64]; ↑ in CSF [65]
NGF	↑ in brain [68]
proBDNF		↓ in brain [59, 60]
BDNF		↓ in brain [59, 60]
p75NTR	↑ in brain [68,69,70,71]; ↑ in serum [72, 73]	↓ in CSF [72, 73]
TRKA		↓ in brain [59, 74,75,76,77]
TRKB		↓ in brain [77]
TRKC		↓ in brain [77]

ISSN: 1750-1326