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Table 3 Reported functional interactions of VPS10p-D receptors with components of neurotrophin signaling

From: Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease

NEUROTROPHIN SIGNALING

VPS10p-D RECEPTORS

SorLA

Sortilin

SorCS1

SorCS2

SorCS3

proNGF

 

• [52, 53, 134]

 

• [55, 132, 135]

 

NGF

 

• [52]

 

• [135]

• [136]

proBDNF

 

• [134]

x [113]

 

• [54, 132, 135]

 

BDNF

x [137]

• [117, 138]

 

• [36, 54, 139]

 

proNT3

 

• [140, 141]

   

p75NTR

 

• [52, 53, 134]

x [113]

 

• [55, 132]

 

TrkA

 

• [142]

   

TrkB

• [143]

• [142]

• [144]

• [54]

• [144]

TrkC

 

• [142]

   
  1. • - Functional interaction
  2. x - Transcriptional changes (indirect interaction)
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Molecular Neurodegeneration

ISSN: 1750-1326