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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Fig. 3

The emergence of disease stage-dependent microglia subtypes coincides with Aβ and tau deposition. A UMAP plot showing microglia clusters in the 6- and 12-month-old cortex (all genotypes) (left) and UMAP plot with RNA velocity (right) showing 2 potential transitions between DAM1 and LADAM, with transitions into EADAM and/or DAM2 in between. B UMAP plot showing the density of the captured microglia clusters across genotypes in the 12-month-old cortex. C Pseudotime analysis showing gene expression changes between DAM1, DAM2, and LADAM. D Pseudotime analysis showing gene expression changes between DAM1, EADAM, and LADAM

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Molecular Neurodegeneration

ISSN: 1750-1326