Fig. 4
From: APOE effects on regional tau in preclinical Alzheimer’s disease
Mediating effects of amyloid (centiloids) on APOE and regional tau SUVRs. (A) Stacked bar plots depict the total effect, as well as indirect and direct subcomponents, extracted from mediation models examining the effects of APOE on regional tau among Aβ+ clinically unimpaired (CU) individuals from A4. A comparison of e2 and e4 direct effect sizes are also shown. Error bars reflect standard error. (B) Stacked bar plots depict the total effect, as well as indirect and direct subcomponents, extracted from mediation models examining the effects of APOE e4 on regional tau among Aβ+ CU and mild cognitive impairment (MCI) individuals from ADNI. Note: * p < 0.05, **p < 0.01, ***p < 0.001