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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

Fig. 6

Gene set enrichment analysis in all biochemical measures. Gene set enrichment was performed via GSA-SNP2 with the MiSigDB (c5.all.v5.2). Significantly enriched pathways (q-value < 0.05) were matched with Gene Ontology (GO) IDs and input in REViGO for reduction of redundant pathways and summarization. Significant pathway groups from REViGO and the highest p-value of that group are plotted in bar plots for each protein. X-axis = −log10(P-value), Orange = soluble (TBS) fraction, Blue = membrane (TX) fraction, Green = insoluble (FA) fraction

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Molecular Neurodegeneration

ISSN: 1750-1326