Table 1 Substrates and substrate candidates of BACE1 identified by NHP pharmacoproteomicsa
UniProt AC | Gene | Protein Name | log2 fold change (100 mpk MBI-4/Vehicle) | log2 fold change (3 mpk MBI-4/Vehicle) | P (100 mpk MBI-4/Vehicle) | P (3 mpk MBI-4/Vehicle) |
|---|---|---|---|---|---|---|
A0A1D5QZV9 | APLP1 | Amyloid-like protein 1 | −0.39 | − 0.62 | 1.20E-02 | 1.97E-02 |
F7FJ90 | APLP2 | Amyloid-like protein 2 | −0.48 | −0.40 | 7.79E-03 | 2.36E-02 |
F7ELT5 | APP | Amyloid beta A4 protein | −0.41 | −0.52 | 1.85E-03 | 3.07E-02 |
F6Y3S7 | BSG | Basigin | NaN | −0.98 | NaN | 1.22E-02 |
F7B8S4 | CHL1 | Neural cell adhesion molecule L1-like protein | −0.27 | −0.31 | 1.37E-02 | 9.60E-02 |
F6ZIK5 | CNTN2 | Contactin-2 | −0.48 | −0.36 | 1.26E-02 | 3.30E-02 |
F7A4T4 | FGFR1 | Fibroblast growth factor receptor 1 | −0.50 | −0.23 | 2.40E-03 | 3.64E-01 |
F7FXB6 | IL6ST | Interleukin-6 receptor subunit beta | −1.12 | −0.72 | 1.45E-03 | 1.00E-02 |
A0A5F7ZLI9 | L1CAM | Neural cell adhesion molecule L1 | −0.20 | − 0.47 | 3.32E-01 | 4.45E-02 |
F6R6D9 | LRRN1 | Leucine-rich repeat neuronal protein 1 | −0.53 | −0.61 | 6.12E-02 | 2.54E-02 |
F7DWH2 | PTPRD | Receptor-type tyrosine-protein phosphatase delta | −0.30 | −0.18 | 4.02E-03 | 1.39E-01 |
F7EHH7 | PTPRG | Receptor-type tyrosine-protein phosphatase gamma | −0.27 | −0.25 | 4.15E-03 | 6.42E-02 |
F7F6J3 | SEZ6 | Seizure protein 6 homolog | −1.48 | −1.37 | 3.64E-06 | 9.83E-04 |
F7GPP8 | SEZ6L | Seizure 6-like protein | −0.57 | −0.39 | 1.87E-03 | 3.02E-02 |
F6Q1B1 | TGFBR2 | TGF-beta receptor type-2 | NaN | −0.92 | NaN | 1.02E-02 |
P60030 | TGOLN2 | Trans-Golgi network integral membrane protein 2 | −0.37 | −0.59 | 3.72E-01 | 2.43E-02 |
F6W7X9 | VCAM1 | Vascular cell adhesion protein 1 | −0.96 | −0.40 | 4.20E-03 | 2.29E-02 |