Fig. 5

Astrocytic APOE removal protects against dystrophic neurites. a–d, LAMP1 staining for dystrophic neurites (a) with quantification of the percentage of total LAMP1 in the cortex (b), percent area coverage of LAMP1 staining around CAA normalized to percent area covered by X34⁺ CAA (c), and percent area coverage of LAMP1 staining around plaques normalized to percent area covered by X34⁺ plaques (d). Scalebar: 200 µm. Purple arrowheads: LAMP1 around plaques. Blue arrowheads: LAMP1 around CAA. Data expressed as mean ± SD, student’s t-test (two-sided) performed for all statistical analyses except (b) and (c), where Welch’s t-test was performed. ∆ = males, ○ = females. *P < 0.05, **P < 0.01, ****P < 0.0001. No other statistical comparisons are significant unless indicated