BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

Table 1 Differentially expressed genes in Bace1-deleted astrocytes

Gene Symbol	Gene Name	avg_log2FC	-log10(p_val)	Function	Citation
Ttr	Transthyretin	1.117156	132.9195	Amyloid related	[61]
Cxcl14	C-x-c motif ligand 14	3.061096	93.76337	Tau related, protein changes	[53]
Sparc	Secreted Protein Acidic And Cysteine Rich	0.76606	51.25117	Synaptic maintenance	[62]
Npy	Neuropeptide Y	1.82274	49.92431	Synaptic maintenance	[63]
Itm2b	Integral membrane protein 2B	0.46628	43.56427	Synaptic maintenance	[64]
Igf1	Insulin growth factor 1	1.500563	40.94406	Insulin or insulin growth factor signaling	[65]
Ctsl	Cathepsin L	0.807468	37.51631	Amyloid related	[66]
Cav1	Caveolin 1	1.235155	36.40204	Amyloid related, synaptic maintenance	[67, 68]
Igfbp7	Insulin growth factor binding protein 7	2.358861	32.96275	Insulin or insulin growth factor signaling	[69]
Junb	Junb	-0.40882	16.06157	AP-1 Transcription family	[56, 70]
Aqp4	Aquaporin 4	-0.40882	16.06157	Amyloid related	[71]
Fos	Fos	0.865464	13.75286	AP-1 Transcription family	[56, 70]
Clu	Clusterin	0.267696	6.670486	Amyloid related, protein changes	[27, 51, 72]
Timp3	TIMP Metallopeptidase Inhibitor 3	0.338117	6.511402	Amyloid related	[73]
Jun	Jun	0.583823	4.81512	AP-1 Transcription family	[56, 70]

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