Fig. 10

CSF ApoA1, ApoE and total protein content significantly correlate with SAA time variables. A representative SAA ThT fluorescence traces relative to samples producing the shortest (NC1, TTT = 12.8 h), median (NC2, TTT = 15.8 h) and longest (NC3, TTT = 20.3 h) TTT averaged on three replicates. All ThT fluorescence traces are represented as average intensity over 3 replicates with error bars representing the SEM. B Heatmap summarizing correlations (Pearson’s) between SAA kinetic parameters and Log2-transformed CSF ApoA1, ApoE, ApoA1 + ApoE, and total protein. Hierarchical clustering was performed by using Ward linkage criterion. C-F scatter plots with detail of Pearson’s correlation coefficients and relative p-value for TTT vs Log2-transformed CSF concentrations (originally in μg/mL) of ApoA1 (C), ApoE (D), total protein (E), and ApoA1 + ApoE (F). Linear regression lines with their 95% confidence intervals (dotted lines) are also displayed