Fig. 7

HDL and LDL impede α-syn aggregation more efficiently than TTR. Lipoproteins exert their anti-aggregation properties by interlacing to early protofibrillary/oligomeric species. A-B Fitted kinetic parameters of a Protein aggregation assay performed using 0.7 mg/mL of recombinant α-syn in PBS with different concentrations of LDL, HDL and TTR. The average fluorescence of three replicates containing the same amounts of LDL, HDL and TTR without α-syn was subtracted prior to the analysis. C-H TEM images relative to the final products obtained using (C-D) α-syn alone (0.7 mg/mL), (E) LDL 0.3 mg/mL alone, (F) HDL 0.3 mg/mL alone, and a combination of both α-syn 0.7 mg/mL + LDL 0.3 mg/mL (G) or HDL 0.3 mg/mL (H)