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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

Fig. 4

Comparison of structural properties of ApoE isoforms at different self-association states. (A) LC-MS/MS analysis of NTD of ApoEWT and ApoEM proteins. (B) Comparison of ApoEWT (the upper panel) and ApoEM (the lower panel) mean deuterium uptake after 60 s. ApoE3 and ApoE4 isoforms are shown in grey and yellow, respectively. The data were determined in 3 time intervals (60s, 120 and 600 s) and error bars represent standard error of mean (SEM). (C) Dissociation of ApoE3 (grey) and ApoE4 (yellow) dimeric units during MD simulations.

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Molecular Neurodegeneration

ISSN: 1750-1326